The immune system is the body’s natural defense network, relying on white blood cells, antibodies, and cellular signaling pathways to help maintain overall wellness. Supporting healthy immune function involves providing essential amino acids, antioxidants, and enzymes that contribute to immune cell production, signaling, and protection from oxidative stress.

SUPREMEplex™ LP² is formulated with a comprehensive LP² matrix that includes ingredients studied for their roles in supporting the body’s own immune processes.

L-Lysine and L-Histidine L-Lysine and L-Histidine are essential amino acids included in the LP² matrix and have been researched for their contributions to immune cell development and function. Lysine supports the production of antibodies and antimicrobial peptides that help the immune system interact with microbes. Histidine, as a precursor to histamine, plays a role in normal immune signaling and helps regulate white blood cell activity during immune responses.

L-Glutathione and N-Acetyl Cysteine (NAC) L-Glutathione is widely recognized as a master antioxidant that helps protect immune cells from oxidative stress and supports their optimal function. NAC serves as a direct precursor to glutathione and is studied for its ability to replenish glutathione levels, thereby contributing to healthy immune activity and natural defense mechanisms.

Bromelain Bromelain, the proteolytic enzyme in the LP² matrix, has been researched for its ability to support a balanced inflammatory response, which in turn helps maintain normal immune function. By helping modulate certain immune signaling pathways and supporting tissue comfort, bromelain contributes to overall immune wellness.

Amino Acids & Bioactive Peptides in the LP² Matrix The full LP² matrix delivers a rich profile of amino acids and bioactive peptides that serve as building blocks for immune proteins, antibodies, and cellular repair—further supporting the body’s natural immune defenses.

Together, L-Glutathione, NAC, bromelain, L-Lysine, L-Histidine, and the amino acids in the LP² matrix work synergistically in SUPREMEplex™ LP² to support healthy immune function, natural detoxification pathways, healthy inflammatory response, antioxidant activity, and the body’s own ability to maintain microbial balance.

References

1. Wu G, et al. Glutathione metabolism and its implications for health. J Nutr. 2004;134(3):489-92.
2. Ghezzi P. Role of glutathione in immunity and inflammation in the lung. Int J Gen Med. 2011;4:105-113.
3. dos Santos Tenório MC, et al. N-Acetylcysteine (NAC): Impacts on Human Health. Antioxidants. 2021;10(7):967.
4. Askari M, et al. The effects of N-Acetylcysteine on serum level of inflammatory biomarkers in adults: A systematic review and meta-analysis. Cytokine. 2020;136:155282.
5. Pavan R, et al. Properties and Therapeutic Application of Bromelain: A Review. Biotechnol Res Int. 2012;2012:976203.
6. Rathnavelu V, et al. Potential role of bromelain in clinical and therapeutic applications. Biomed Rep. 2016;5(3):283-288.
7. Andou A, et al. Dietary Histidine Ameliorates Murine Colitis by Inhibition of Proinflammatory Cytokine Production from Macrophages. Gastroenterology. 2009;136(2):564-574.
8. Wang G. Human antimicrobial peptides and proteins. Pharmaceuticals. 2014;7(5):545-94.
9. Zheng X, et al. The role of amino acid metabolism in inflammatory bowel disease. Front Immunol. 2023;14:1123912.