What is the Serving size for the SUPREMEplex™?
Nasal Spray Usage Guidelines Our recommended usage is printed directly on the bottle. Most people start with one squirt in each nostril once per day. For more acute symptoms, your practitioner may recommend a more aggressive initial approach — such as two squirts in each nostril twice daily for the first three days — then gradually tapering off as symptoms improve. The initial burning sensation most people experience typically subsides as the nasal passages adjust to the higher pH over time.
LP2 Oral dropper Bottle (our original postbiotic) Usage Guidelines:
- Under 200 lbs: 1 teaspoon per day.
- Over 200 lbs: 2 teaspoons per day.
LP3 MEGA Biotic Usage Guidelines: 1Tablespoon per day
As with any natural supplement, some individuals may experience temporary adjustment symptoms when first starting. If this occurs, we recommend decreasing your serving size and consulting your licensed healthcare practitioner for guidance.
Protocol Duration
Minimum of 48 days recommended, with a 3-6 month protocol for maximum effectiveness.
Herxheimer Reactions
If prone to reactions, start with 1/2 teaspoon daily and gradually increase to 1 teaspoon. Consult a healthcare provider about “microdosing” if you have a history of sensitivity to Lyme disease protocols.
*If you know you are prone to Herxhiemer reactions, start with 1/2 a teaspoon a day and work your way up to the full 1 teaspoon per day serving or speak with your healthcare provider about “microdosing” if you have a history of being HIGHLY SENSITIVE to Lyme disease protocols.
I am still confused about the ingredients, please tell me more
Our key ingredient, LP²™, creates an environment in your body, that not only enhances and boosts the immune system, but it also empowers it to do what a healthy immune system was designed to do: The immune system protects the body from harmful influences in the environment, like a guard, and is vitally important for the body. It is made up of different organs, cells, and proteins. Aside from the nervous system, it is the most complex system in the human body. LP²™ is comprised of a variety of amino acids, peptides, enzymes, and proteins.
Amino Acid Profile
Following is a list of the Amino Acids (one group of important components) verified as present in the LP²™ formulation: Glutamic Acid, Arginine Serine, Aspartic Acid, Threonine, Valine, Lysine, Isoleucine Phenylalanine, Alanine, Histidine, Tyrosine, as well as Trace Enzymes and Peptides
While it would be technically accurate to refer to them as “ingredients”, we prefer to refer to them as “component parts” or “element parts” because none of the amino acids were added to our proprietary process. They were all produced within it. This is why the product is so unique. The actual number of different amines within the LP²™ product is far beyond that listed above. When asked why one couldn’t simply combine all of the listed amino acids into a mixing process and assume it to be equivalent, we will often provide our “apple analogy” as follows:
You see, you can only determine and isolate the “ingredients” (component/element parts) of an apple in a scientific laboratory up to the limits of the available technology. Upon determining all that we can appreciate regarding what an apple is comprised of, we still cannot take all of those “ingredients” and reproduce an apple exactly as nature does. Much would still be missing. An apple must be grown using a very complex process in order to get a true reproduction of the apple with all of its benefits intact. Even then, if conditions or resources are deficient or even slightly compromised it may fail to yield the desired result.
“Although a tree is common and familiar to all of us, how a tree grows, functions and its unique biology is not so familiar. The interrelationship of all a tree’s parts is very complex…” – Steve NixsFiltered water, Amino Acids (Glutamic Acid, Arginine Serine, Aspartic Acid, Threonine, Valine, Lysine, Isoleucin Phenylalanine, Alanine, Histidine, Tyrosine), Trace Enzymes and Peptides
Why does SUPREMEplex™ smell like ammonia?
LP2 is a postbiotic dietary supplement made through a proprietary bio-fermentation process using a specific consortium of spore-forming bacteria. During fermentation, these microbes naturally break down nitrogen-containing compounds (including amino acids and other substrates) as part of their metabolic activity.
One of the normal by-products of this process is ammonia — a colorless gas with a distinct, sharp odor. In small amounts, this ammonia contributes to the characteristic scent of the liquid concentrate and is completely normal for many fermented, nitrogen-rich biological products (similar to the smell of certain aged cheeses, fermented soy products, or some protein hydrolysates).
Key points:
- The ammonia odor is not from the final product being “spoiled” or unsafe — it is a natural result of the controlled fermentation.
- The product is fully inactivated (heat-treated to eliminate live microbes) and rigorously tested (COA, toxicology, heavy metals) to ensure safety and quality.
- Most customers find the odor mild and temporary when diluted in water or juice, or when taking capsules/powder forms.
- We are actively working on formulation improvements in our upcoming cGMP production to further reduce any noticeable odor while preserving the full bioactive profile.
We appreciate your understanding — and we’re grateful you’re part of the SUPREMEplex family!
If the smell is bothersome, try:
- Diluting in 4–6 oz of water or juice
- Taking with food
- Using the capsule or powder form
Thank you for your support and feedback — it helps us continue improving.
Why did I develop a rash after starting the SUPREMEplex™?
SKIN MANIFESTATIONS in LYME DISEASE
By Arthur Gertler, L.L.M.D.
It is not unusual to see skin eruptions in the treatment of Lyme disease, especially early in the course when Herxheimer reactions appear. It is due to the dissemination of toxins and immune complexes arising in the gut and migrating to the skin, where it causes a variety of dermatitis manifestations. Lyme overgrows the bowel after it attacks the nervous system, and when treatment begins, it breaks down yielding toxins, antigens and immune complexes which naturally migrate to the inert depot the skin, away from vital internal organs and the brain. In the skin, these will often cause rashes, eczema, psoriasis, rosacea, and acne to appear in sensitive individuals. This is usually only temporary, at the start of Lyme treatment, when there is a wave of spirochete loss, often seen when Herxheimer reactions appear, and recedes later on. Pre-existing dermatitis may exacerbate at this stage as well.
Standard treatment of the dermatitis with SUPREMEplex® serum, aloe, neem, and many other common skin salves is usually effective.
How long can the Humic/Fulvic be mixed before drinking or does it matter if it’s a few hours?
If you mix the humic/fulvic powder with water it is fine to drink it over the day or a few hours. Lots of people add it to their water bottles and do this. I wouldn’t leave it out for a long time though, as airborne mold spores, bacteria and other contaminants can get into it (just like with plain water).
Do I need to take SUPREMEplex™ with food?
No, the bioavailability (it enters the circulation when introduced into the body and so is able to have an active effect.) is rapid. The liquid goes into the bloodstream within 1-4 minutes.
Can I take the SUPREMEplex™ with other medications or supplements?
There are no known interactions reported by doctors, with pharmaceutical drugs or natural supplements.
Does Mast Cell Activation Syndrome (MCAS) Go Away After Recovering from Lyme Disease?
Many Lyme disease sufferers wonder if Mast Cell Activation Syndrome (MCAS)—a condition where mast cells overreact and cause symptoms like fatigue, brain fog, and allergic reactions—will resolve once they recover from Lyme bacteria. While reducing the Lyme bacterial load can help lessen MCAS symptoms by removing a major trigger, MCAS doesn’t always fully go away. Lyme disease often activates mast cells, leading to immune dysregulation, but even after the infection is addressed, mast cells can remain hypersensitive to other triggers like environmental toxins, stress, or food sensitivities. Factors such as mold exposure or gut dysbiosis, which are common in Lyme patients, can also perpetuate MCAS if not managed.
At SUPREMEplex™, we’ve seen many customers experience improvement in MCAS symptoms as they recover from Lyme, thanks to the supportive properties of LP2 and LP3 MEGA-biotic. LP2’s detox capabilities can help clear lingering infections, while LP3 MEGA-biotic’s pre-pro-postbiotic blend supports gut health and immunity—key factors in managing MCAS. However, ongoing management, such as a low-histamine diet, stress reduction, and addressing co-triggers, may still be necessary. Working with a Lyme-literate practitioner can help identify and manage these factors, ensuring a more comprehensive recovery. We’re here to support you every step of the way!
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a healthcare professional before starting any new supplement or therapy.
PTSD in Lyme Disease Recovery: Overcoming Fear of Symptom Return
For many Lyme disease sufferers, the journey to recovery is not just physical but deeply emotional. A lesser-discussed challenge is the post-traumatic stress disorder (PTSD) that can emerge after years of battling chronic symptoms like fatigue, joint pain, and brain fog. For some, even a typical flu or cold can trigger intense panic, as they fear their Lyme symptoms are returning. This anxiety is understandable—Lyme disease often leaves a lasting impact, and the uncertainty of recovery can make any new symptom feel like a relapse. Research shows that chronic illnesses like Lyme can lead to PTSD, with patients experiencing hypervigilance and fear of recurrence, especially when common illnesses mimic Lyme’s symptoms.
At SUPREMEplex™, we understand this fear and are here to support your holistic recovery. Products like LP2 and LP3 MEGA-biotic can help by supporting your immune system and reducing inflammation, which may ease the severity of symptoms during illnesses like the flu. Many of our customers have found that as their Lyme burden decreases, their confidence in their body’s resilience grows, helping to reduce panic over time. Alongside this, strategies like stress management, mindfulness, and working with a Lyme-literate practitioner can help address PTSD, empowering you to navigate recovery with greater peace of mind.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a healthcare professional before starting any new supplement or therapy.
Why are some of my friends having more symptom relief than I am?
The variables are broad, with this question, as with any supplement or drug, for that matter. Your practitioner has to take into account the number of co-infections; levels of toxins present in the body; length of illness; how compromised your immune system is; your diet, self-care habits (are you getting enough rest and managing your levels of stress?); level of Metabolic health; number of herbs, supplements, and pharmaceutical side effects; (some mimic Lyme symptoms) and more factors, that your health care provider can advise you on.
Can we take amino acid supplements daily?
Amino Acid supplements are generally safe to use every day. Depending on our unique health needs, it may take a little experimenting to determine how much our body needs, as every person’s nutritional needs are different.
How long do I have to take the products to get lasting results?
The key question here is the term “results.” We are on a learning curve with this question, with Lyme disease and its co-infections. We had it somewhat dialed in, with the Autoimmune diseases, for years. However; Lyme disease is an entirely different story. We’ve had customers feel comfortable with discontinuing use after using one eight-ounce bottle. While other customers are taking six months or more before they are comfortable going off this supplement. Another more obvious consideration must be, any other protocols that you are taking. Many pharmaceutical drugs; herbs; and supplement protocols; have side effects. Often those very side effects can mimic Lyme disease or its co-infections’ symptoms.
There are many other variables in a person’s overall health to consider as well. Our customers tend to be quite educated about this disease and understand much of what we are speaking of here. Some of them get re-tested and allow their results to define their personal decision. Hence, we are no longer suggesting a standard length of treatment.
At this point in time, the first Licensed Health Practitioner to begin using SUPREMEplex® specifically for Lyme disease, presently recommends 4-6 eight-ounce bottles on average. As our current case studies are conducted and formally analyzed, and clinical trials get underway; we shall update this section here on our website and our newsletters. And, as we make clear on our Landing Page: we highly recommend that you consult with a Lyme literate, Licensed Health Practitioner; as they can more effectively guide you in making the determination of the length of protocol and causation of remaining symptoms if any are present.
Do you need to take SUPREMEplex™ on an empty stomach?
No, our oral liquid supplement goes into the bloodstream within 1-4 minutes.
Should I take SUPREMEplex™ in the morning?
You can take it at any time throughout the day.
Do you take the SUPREMEplex™ with the Humic/Fulvic Acid?
No, we suggest that you take our Humic Acid/Fulvic Blend three hours apart from the SUPREMEplex™. This gives the antibacterial and antifungal properties time to work through the system and then the Humic Acid antiviral can do the same.
What is a Herxheimer Reaction?
Although our customers report minimal Herxing with SUPREMEplex™, you may have to go through it to get to it.
A Herxheimer reaction is the side effects of effective treatment or cleansing. It is a normal reaction your body has when toxins from dead pathogens are being dumped into the bloodstream faster than the body can comfortably handle.
Common Symptoms Include:
- Nausea
- Headache
- Fatigue
- Joint Pain
- Muscle Pain
- Cold Sweats
- Fever
- Chills
Herxheimer reactions are not necessarily a bad thing. They are a good indication that the body is healing, and toxins are being eliminated.
“A typical Herx reaction can last anywhere from a week to a few months. Each case is different and there are many factors at play when estimating how long the reaction will last. The biggest factor at play is the condition and status of what is being treated (i.e. condition of skin lesions, status of Lyme disease, etc…). Other factors that come in to play include how effectively the body can remove toxins and debris from the blood, and how healthy the body is overall.”
Be sure to get extra rest, stay hydrated, and allow your body to reset, as you detox. Always check in with your Practitioner if your discomfort is concerning to you.
The most important thing to remember during any type of treatment or cleansing is that a Herx reaction is a good thing, and the protocol should be continued if the Herxing is not extreme.
Taking a day or two break and/or reducing the serving size or doctor prescribed dosage, is the simple answer to reducing your Herxing. And then, building back up to a comfortable tolerance is the best approach to your healing process.
What are the most common supplements that are taken for Lyme disease?
Alpha lipoic acid 200mg daily
Fish oil 5 gms daily
N-acetylcysteine 1000mg daily (precursor to glutathione)
Multivitamins (natural)
Vitamin D3 5000u daily
probiotics 20-40 billion daily
Sometimes add vitamin C 2000mg
Sometimes add Magnesium (not oxide) 500mg
Is it known if the amino acids in SUPREMEplex™ LP2 are helpful in managing MCAS?
Regarding Mast Cell Activation Syndrome (MCAS), we do not make any specific medical claims about SUPREMEplex™ treating, curing, or managing MCAS, as it is not positioned or approved as a medical treatment for the condition. That said, certain amino acids in the formula (such as histidine, glycine, and glutamine) play important roles in supporting histamine metabolism, gut barrier function, and modulating inflammatory responses — all of which can be relevant for people navigating MCAS symptoms.
